缺血修饰白蛋白的检测在急性冠脉综合征早期诊断中的意义

The Value of Ischemia Modified Albumin in Early Diagnosis of Acute Coronary Syndrome

目的探讨血清缺血修饰白蛋白在急性冠脉综合征早期诊断中的意义。方法选择80例急性冠脉综合征患者,其中不稳定型心绞痛组35例;心肌梗死组45例。分别于胸痛发作2、4、6、12、24 h采静脉血检测其缺血修饰白蛋白的水平,并与正常对照组比较,分析缺血修饰白蛋白对急性冠脉综合征患者早期诊断的意义。结果不稳定型心绞痛和心肌梗死患者胸痛2、4 h缺血修饰白蛋白水平均明显高于正常对照组,差异有统计学意义(P<0.05),而胸痛6、12、24 h缺血修饰白蛋白水平与正常对照组比较,差异无统计学意义(P>0.05);胸痛2、4 h的缺血修饰白蛋白水平明显高于同组胸痛6、12、24 h,差异有统计学意义(P<0.05)。结论检测缺血修饰白蛋白的水平对于急性冠脉综合征早期诊断及治疗有一定临床价值。

Objective To study the value of ischemia modified albumin （IMA） in the early diagnosis of acute coronary syndrome （ACS）. Methods Eighty patients with ACS, among whom there were 35 with unstable angina and 45 with acute myocardial infarction, were selected into the study. Their serum concentration of IMA was measured respectively at 2, 4, 6, 12 and 24 hours after the onset of chest pain. Results The serum levels of IMA in those with unstable angina and acute myocardial infarction at 2 and 4 hours after the onset were significantly higher than that in normal controls （ P 〈 0.05 ） ; in those with unstable angina and acute myocardial infarction, the serum levels of IMA were significantly bigher at 2 and 4 hours than at 6, 12 and 24 hours after the onset of chest pain （ P 〈 0.05）. Conclusion The detection of serum levels of IMA is of important value in early diagnosis and treatment of ACS.