BIRC5的表达与大肠癌淋巴结转移的关系

Relationship of BIRC5 Expression to Colorectal Cancer Lymphatic Metastasis

目的探讨凋亡抑制基因BIRC5是否参与大肠癌发病过程及是否与淋巴结转移相关。方法利用免疫组织化学方法分析比较40例大肠癌组织及其自体正常大肠组织,以及35例癌细胞淋巴结转移组织中BIRC5蛋白的表达情况。结果BIRC5蛋白在癌组织中的表达程度与非癌组织(正常大肠组织)比较,差别有统计学意义(P<0.001)。在淋巴结转移的癌组织中,BIRC5蛋白的表达与非淋巴结转移的大肠癌组织比较,差别亦有统计学意义(P<0.01)。结论BIRC5参与了大肠癌发病过程,并与癌细胞淋巴结转移相关。

Objective To find out whether BIRC5, an apoptosis suppressor gene, is involved in the pathogeneses of colorectal cancers, and its relationship to lymphatic metastases. Methods Immunohistochemistry was used to analyze and compare the BIRC5 expressions in the colorectal cancer and normal colon tissues （40 cases） , and in the cancer lymphatic metastasis tissues （35 cases）. Results BIRC5 expression was higher in the colorectal cancer tissues than in the normal （ P 〈 0. 001 ）, and higher in the tissues of colorectal cancer lymphatic metastases than in primary colon cancer （ P 〈 0.01 ）. Conclusion Increased expression of BIRC5, which may promote the pathogeneses of colon cancers, is associated with colorectal cancer lymphatic metastases.