2型糖尿病患者心室肥大与血浆脑利钠肽浓度的关系

RELATIONSHIP BETWEEN VENTRICULAR HYPERTROPHY AND BRAIN NATRIURETIC PEPTIDE CONCENTRATION IN NIDDM PATIENTS

用固相免疫分析方法测定了１６０例正常对照和３７１例２型糖尿病患者的血浆ＢＮＰ浓度。结果：测定值分别为１０．５±８．１４ｐｇ／ｍｌ和２７．１±５０．４ｐｇ／ｍｌ；摄Ｘ线胸片并计算心胸比（ＣＴＲ），分别为４３．９６％±４．１９％和４７．５９％±５．４３％。糖尿病患者按ＣＴＲ值分ＣＴＲ正常组和异常组，ＣＴＲ值分别为４４．５３％±３．４１％和５３．４０％±３．４３％；血浆ＢＮＰ值分别为２０．９±３１．５ｐｇ／ｍｌ和３８．９±７２．８ｐｇ／ｍｌ；平均动脉压值（舒张压＋１／３脉压差）分别为９．３５±１．４８ｋＰａ和１０．０５±１．４９ｋＰａ。研究结果表明：２型糖尿病患者ＢＮＰ和ＣＴＲ值均明显高于对照组。

160 non_diabetic control subjects and 371 type 2 diabetes mellitus were selected for the measurement of brain natriuetic peptide (BNP) by immunoradiometric assay. The BNP level for healthy control was 10.5±8.14pg/ml and for diabetics 27.1±50.4pg/ml. Cardiothoracic ratio (CTR) calculated from chest film for non_diabetic control was 43.96%±4.19% and for diabetics 47.59%±5.43%. According to the valueofCTR, thediabeticswere subdivided into normal CTR group and high CTR group, CTR value being 44.53%±3.41% and 53.40%±3.43% respectively. For normal CTR group, plasma BNP value was 20.9±31.5 pg/ml and mean blood pressure was 9.35±1.48kPa; and for high CTR group, 38.9±72.8pg/ml and 10.05±1.49kPa respectively. The results suggest that the BNP and CTR values of type 2 diabetes mellitus patients are obviously higher than those of non_diabetics, and the BNP and mean blood pressure of the high CTR group are very significantly higher than those of the normal CTR group.