摘要
以大鼠乙酸－消炎痛胃溃疡为动物模型，用甲氰咪胍作为对照药，观察了丹参提取物Ｆ对溃疡愈合过程的影响及其与胃粘膜微循环、粘膜细胞再生、胃壁结合粘液分泌的关系。结果表明，丹参提取物Ｆ组的溃疡指数和溃疡边缘毛细血管网眼面积明显低于对照组和低于甲氰米胍组，而溃疡边缘粘膜血流量、细胞标记率及胃壁结合粘液量明显高于对照组，亦高于甲氰咪胍组。提示：丹参提取物Ｆ能促进大量乙酸－消炎痛胃溃疡的愈合，其作用优于甲氰咪胍。其机制可能与改善胃粘膜微循环、边速粘膜细胞的再生、促进粘液分泌有关。
Using rats with redoubtable gastric ulcer induced by acetic acid-indomethacin animal model,use cimetidine as control.The effects of DSE-F on the healing process of redoubtable gastric ulcer and the relation to gastric mucosal micro-circulation,mucosal cells regeneration and gastric wall binding mucus secretion were observed.The results were as following:ulcer index in DSE-F group and ulcer marginal meshed vascular area were significantly decreased than NS control group and imetidine control group.Ulcer marginal mucosal blood volume,cell labelling rate and the amount of gastric wall binding mucus is significantly increased than NS control group and cimetidine control group.All these results suggest:DSE-F enhanced healing of acetic acid-indomethacin induced redoubtable gastric ulcer in rats and its healing effects were better than cimetidine.The mechanisms lie in the increasing of ulcer edge mucosal micro-circulation,mucosal cell regeneration and mucus secretion.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1997年第5期479-482,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
