胆囊收缩素对内毒素性休克大鼠SOD、MDA及吞噬细胞发光的影响

Effect of cholecystokinin on SOD、MDA contents and phagocyte chemiluminescence of reversing endotoxin shock rat

以ＳＤ大鼠ＥＳ（内毒素休克，内毒素０．８ｍｇ／１００ｇｂ．ｗ．ｉｖ）为模型，观察了ＣＣＫ－８抗ＥＳ过程中平均动脉血压（ＭＡＰ），血液超氧化物歧化酶（ＳＯＤ），脂质过氧化产物丙二醛（ＭＤＡ）及吞噬细胞化学发光（ＰＣＬ）的变化。实验结果：ＣＣＫ－８可使ＥＳ大鼠ＭＡＰ回升，血浆ＳＯＤ活性升高（Ｐ＜０．０１），ＭＤＡ含量减少（Ｐ＜０．０５）；吞噬细胞本底发光增强、峰值增高、峰时缩短（Ｐ＜０．０５）。结果表明ＣＣＫ在抗ＥＳ过程中可提高ＳＯＤ的活性，降低ＭＤＡ含量和增强吞噬细胞的吞噬功能。提示ＥＳ时ＣＣＫ对机体具有重要的保护作用。

It has been reported that blood cholecystokinin(CCK)level was increased during endotoxemia and endotoxin shock(ES).Recently it was found in our department that CCK-8 could reverse experimental endotoxin shock.The rat model of ES(endotoxin 0.8mg/100gb.w.iv)was used to observe the changes of mean arterial pressure (MAP),blood SOD、MDA and phagocyte chemiluminescence(PCL) during CCK reversing ES.The results showed that MAP was elevated(P<0.05),activity of plasma SOD was increased(P<0.01),MDA content was decreased(P<0.05),the background and peak value of PCL were enhanced as well as the peak time was reduced(P<0.05)after CCK injecting in ES rats.It is suggested that CCK could increase SOD activity,decrease the MDA content,and enhance the functions of phagocyte during CCK reversing.ES,CCK has importent protective action in ES.