替硝唑对厌氧菌体外抗菌活性的研究

In vitro susceptibility of anaerobic bacteria to tinidazole

测定了替硝唑对临床分离的１４８株厌氧菌和２株标准株的ＭＩＣ，确定替硝唑对革兰氏阴性厌氧菌活性最强，其ＭＩＣ为０．０６２～１ｍｇ／Ｌ，它们对梭菌的ＭＩＣ为０．２５～０．５ｍｇ／Ｌ，对革兰氏阳性无芽孢厌氧杆菌，除了真杆菌ＭＩＣ为４ｍｇ／Ｌ外，抗菌活性较低，其ＭＩＣ为大于６４ｍｇ／Ｌ，对厌氧球菌也有相当的活性，其ＭＩＣ为０．２５～１．０ｍｇ／Ｌ。

MICs of tinidazole against 150 clinical isolates of anaerobes were determined. Results showed that tinidazole had the strongest activities against Gramnegative anaerobes (MICs range 0.062￣1.0mg/L), and MICs of tinidazole was 0.25￣0.5 mg/L for clostridium. The tinidazole showed low activities against Grampositive nospore anaerobes (except Eubacterium), MIC was >64mg/L, the tinidazole showed certain activities against anaerobic coccus, its MICs range from 0.25 to 1.0mg/L.