兔放射状角膜切开术伤口愈合形态学研究

A Morphologic Study of Wound Healing after Radial Keratotomy in Rabbits

目的研究兔放射状角膜切开术（ｒａｄｉａｌｋｅｒａｔｏｔｏｍｙ，ＲＫ）术后角膜伤口愈合的形态学特征。方法对６组兔放射状角膜切开术后３ｄ，１、２、４周，２、３个月角膜标本进行光镜和电镜观察。结果随着术后时间的延长，上皮栓的宽度持续增加，深度不断减小，成纤维细胞和胶原纤维的排列逐步趋向于平行角膜平面排列，术后３个月时，伤口区胶原板层的连续性得到一定程度的恢复。结论放射状角膜切开术是一种安全有效的屈光手术。

ObjectiveTo determine the morphological features of wound healing after radial keratotomy (RK) in rabbits.MethodsSix groups of rabbits received radial keratotomy.Light and electron microscopic examinations of the cornea were performed at 3 d,1,2,4 wk,2 and 3 mon postoperation.ResultsMeasurement of the epithelial plug showed increasing width and decreasing depth during the observation period.Fibroblasts and collagenous fibers tended to orient transversly.On d 90,collagenous lamellae continued in corneal wound regions in which a certain degree of recovery was regained.ConclusionRK is a safe and effective form of refractive surgery.