谷胱甘肽过氧化物酶和谷胱甘肽转硫酶研究进展

Progress on GSH-Px and GST

谷胱甘肽过氧化物酶(GSH-Px)和谷胱甘肽转硫酶(GST)是一对抗氧化酶。GSH-Px为含硒半胱氨酸,至少有4种同工酶,催化还原H2O2和有机氢过氧化物。GST不含硒,有多种同工酶,不能分解H2O2,但具有清除过氧化物和解毒的双重功能。二者广泛存在于组织细胞、红细胞、血浆和乳中,与细胞损伤、缺氧、中毒、衰老、多种疾病的发生有关;GSH-Px活性也与机体硒水平密切相关。文章综述了GSH-Px和GST的分类与结构、性质、作用、检测原理、动物临床方面的应用及研究进展。

The GSH-Px and GST is a pair of antioxygented enzymes. GSH-Px,is a Cys containing Se,and it has 4 isoenzymes at least. It catalyzes and reduces H2O2 and origannic H-peroxide. GST does not contain Se, but it has many isoenzymes and could not decompose the H2O2. However it has two functions： eliminating peroxide and detoxification. GSH-Px and GST exist greatly in histocytes,erythrocytes, plasma, milk, and closely relate with the damage of cells, anoxia, poisoning,ageing and many diseases. The activity of GSH-Px is closely related with concentration of selenium. This article summarized the research development on types and structure, characters, functions, detection principle, clinical application in animals of GSH-Px and GST.