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7α-羟基-去氢表雄酮的合成与活性测定 被引量：3

Synthesis of 7α-OH-Dehydroepiandrosterone and Evaluation of Its Bioactivity
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摘要 目的合成7α-羟基-去氢表雄酮(7α-OH-DHEA),并对其进行活性测定。方法以薯蓣皂苷元为起始原料,用化学法合成DHEA,再用生物转化法合成7α-OH-DHEA。结果经6步化学反应合成得到了DHEA;筛选出一株对DHEA有转化活性的菌株,经鉴定为曲霉(Aspergillus.),利用曲霉对DHEA转化得到了7α-OH-DHEA,收率为35.0%。结论利用生物转化的方法合成7α-OH-DHEA,步骤少,立体选择性好,污染小,目标产物具有好的免疫调节活性。 OBJECTIVE To study the synthesis of 7α-OH-DHEA. METHODS DHEA was synthesized using chemical synthesis with diosgenin as starting material, and the 7α-OH-DHEA was obtained by microbial transformation. RESULTS The strain isolated from samples collected from different area, was identified as Aspergillus. which could translate DHEA into 7α-OH-DHEA, and the yield was 35.0 percent. CONCLUSION Microbial transformation was a good method because of its less steps, small pollution and good stereo-selectivity. The target compound have good immunocompetence.
作者 李合平 梁冬松 戴贵馥 刘宏民
机构地区 河南中医学院药学院 郑州大学材料科学与工程学院 郑州大学新药研究开发中心
出处 《中国药学杂志》 CAS CSCD 北大核心 2008年第20期1596-1598,共3页 Chinese Pharmaceutical Journal
关键词 去氢表雄酮 7α-羟基-去氢表雄酮 生物转化 曲霉 生物活性 DHEA 7α-OH-DHEA microbial transformation Aspergillus bioactivity
分类号 R914.5 [医药卫生—药物化学]
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参考文献10

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同被引文献27

  • 1于梅艳,姜巧娟.固定化细胞技术在食品工业中的应用研究[J].生物技术世界,2012,9(1):1-3. 被引量：4
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中国药学杂志
2008年 第20期

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