中药土三七致肝小静脉闭塞病临床分析

Clinical analysis of hepatic veno-occlusive disease induced by Sedum aizoon

目的：探讨中药土三七导致肝小静脉闭塞病的临床特点及防范措施。方法：通过检索国内电子专业期刊库收载的1998～2007年国内公开发表的医药学期刊中所有关于服用中药土三七导致肝小静脉闭塞病文献，对报道的41例病例进行综合统计分析。结果：土三七导致肝小静脉闭塞病病情较严重，其发生与患者年龄、服药时间长短以及服药总量有关。结论：为避免土三七导致肝小静脉闭塞病，宜加强土三七的药理与毒理方面的研究，对患者进行安全意识教育，并规范其使用方法和剂量，指导临床合理使用。

Objective： To discuss the clinical characteristics and precautionary measures of hepatic veno-occlusive disease （VOD） caused by Sedum aizoon. Method： The VOD induced by Sedum aizoon were reports in 41 patients comimg from national medical journals from 1998 to 2007 and their use and dose were analyzed. Result： The results shows that ADR of Sedum aizoon was serious. VOD has relationship with it, s dose use time the age of the patients and individual difference. Conclusion： To avoid of VOD induced by Sedum aizoon, it should be done through strengthening study on pharmacology and toxicology of Sedum aizoon. Enhancing patients of safety awareness, standardizing usage and dosage to guide the clinically rational use of drugs.