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Dickkopf-1在妇科恶性肿瘤中的研究进展 被引量：4

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摘要 Dickkopf-1(DKK-1)为Dickkopfs(DKKs)家族的一员,属于一种分泌型糖蛋白,作为Wnt/β-连环蛋白(β-catenin)经典信号传导通路的拮抗剂而受到关注。大量实验证明,DKK-1在诱导肿瘤细胞凋亡,调控肿瘤细胞的骨转移方面以及某些肿瘤细胞的浸润和侵袭方面发挥重要作用。就DKK-1的分子生物学特点、在肿瘤细胞中的信号传导途径和功能,及其在妇科肿瘤中的作用做文献综述。
作者 王诗卓 姜涛 张淑兰
机构地区 中国医科大学附属盛京医院妇产科
出处 《国际妇产科学杂志》 CAS 2008年第5期344-347,共4页 Journal of International Obstetrics and Gynecology
关键词 DICKKOPF-1 信号传导通路 宫颈癌 卵巢癌 滋养细胞肿瘤
分类号 R737.3 [医药卫生—肿瘤] R730 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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同被引文献50

  • 1于彬,余艳军,游海燕,程勤,姚根富,舒惠群,覃文新.肝癌DKK1基因的表达及突变分析[J].肿瘤,2006,26(7):662-665. 被引量：8
  • 2吕讷男,孔为民.宫颈癌耐药基因的表达及其与同步放化疗疗效的关系[J].肿瘤学杂志,2006,12(5):385-388. 被引量：8
  • 3余艳军,万晓桢,于彬,游海燕,舒惠群,姚根富,覃文新.Dickkopf(DKK1)在肝癌组织及多种人肿瘤细胞系中的表达分析[J].肿瘤,2006,26(12):1109-1112. 被引量：16
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  • 6Glinka A, Wu W, Delius H, et al. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction[J]. Nature, 1998, 391,357-362.
  • 7Popovici RM, Kao LC, Giudice LC .Discovery of new inducible genes in in vitro decidualized human endometrial stromal cells using microarray technology[J]. Endocrinology, 2000,141:3510-3513.
  • 8Gonzalez -Sancho JM, Aguiler a O, Garcia JM, et al. The Wnt antagonist DICKKOPF -1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer [J]. Oncogene, 2005, 24 (6): 1098-1103.
  • 9Chamorro MN, Schwartz DR, Vonica A, et al. FGF -20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development [J]. J EMBO, 2005, 24(1): 73-84.
  • 10Valery E. Krupnik, John D. Sharp, Chian Jiang ,et al. Functional and structural diversity of the human Dickkopf gene family [J]. Gene, 1999, 238:301-313.

引证文献4

二级引证文献5

国际妇产科学杂志
2008年 第5期

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