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泛素在妇科肿瘤中的研究进展

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摘要 泛素(Ubiquitin,Ub)是在真核生物中普遍存在的一种高度保守性蛋白质,主要通过泛素-蛋白酶体途径(Ubiquitin proteasome pathway,UPP)参与细胞的多种生理过程,如细胞周期的调控,转录的调节,凋亡的发生及抗原提呈等,进而促进或抑制肿瘤的发生发展。研究证实,细胞周期紊乱是妇科恶性肿瘤的重要作用机制之一。泛素对妇科恶性肿瘤的影响,受到越来越广泛的关注。对泛素在妇科恶性肿瘤方面的进一步研究,可以为妇科恶性肿瘤的早期发现、诊断、治疗和预后提供进一步清晰的方向。
出处 《国际妇产科学杂志》 CAS 2008年第5期347-350,共4页 Journal of International Obstetrics and Gynecology
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