喉癌组织中FAK的表达及临床意义

Expression and clinical significance of focal adhesion kinase in squamous cell carcinoma of larynx

目的检测粘着斑激酶(FAK)在喉鳞状细胞癌中的表达及与侵袭和转移的关系,并探讨其临床意义。方法采用免疫组织化学SP法,观察42例喉鳞状细胞癌组织及40例声带息肉组织中FAK的表达情况。结果喉鳞状细胞癌组织中FAK的阳性率为78.57%,在声带息肉中的阳性表达率为12.50%。喉鳞状细胞癌中FAK的表达与病理学分级及肿瘤临床分型比较差异无统计学意义(P>0.05),与临床分期、颈部淋巴结转移比较差异有统计学意义(P<0.05)。结论FAK在喉鳞状细胞癌的侵袭和转移中起重要作用,可以作为预测侵袭和转移的参考指标之一。

Objective To detect the expression of focal adhesion kinase（FAK）in human laryngeal squamous cell carcinoma and study their correlation in invasion and metastasis. Methods Immunohistochemical S-P method was used to detect the expression of FAK in 42 human laryngeal squamous cell carcinoma and 40 cases of polyp of vocal cords. All the samples were stained by HE method to confirm their pathologic characteristics. Positive rates of FAK were evaluated by microscopy. Results The positive rate of FAK was 78.57 % in human laryngeal squamous cell carcinoma and 12.50 % in polyp of vocal cords, respectively. The difference was significant（P〈0.05）. Moreover,the expression of FAK was higher in the specimen which had been discovered invasion than that in the group without invasion and lymphnode metastasis（P〈0.05）. Conclusion FAK play a key role in the invasion and metastasis of laryngeal squamous cell carcinoma and might prognosticate invasion and metastasis.