国产舍曲林与氯丙咪嗪治疗强迫症的对照研究

The control study of homemade sertraline versus clomipramine in treatment of obsessive-compulsive disorder

目的评价国产舍曲林与氯丙咪嗪治疗强迫症的疗效和安全性。方法对符合CCMD-3强迫诊断标准,分别接受国产舍曲林和氯丙咪嗪治疗的共50例强迫症患者进行为期8周的观察,并应用Yale-Brown强迫量表(Y-BOCS)、Marks恐怖强迫量表(MSCPOR)、HAMD、HAMA和TESS量表评估和比较这2种药物治疗强迫症的疗效和不良反应。结果经过8周治疗,国产舍曲林组与氯丙咪嗪组疗效相近(P>0.05),国产舍曲林组与氯丙咪嗪的显效率(痊愈+显著进步)差异无统计学意义(χ2=0.089,P>0.05)。国产舍曲林组不良反应发生率明显少于氯丙咪嗪组。结论国产舍曲林与氯丙咪嗪对强迫症均有较好的疗效,但舍曲林具有给药方法简便、不良反应轻等优点。

Objective To evaluate the therapeutic effect and safety of homemade sertraline and clomipramine in treatment of obsessive-compulsive disorder. Methods Fifty patients according to CCMD-3 criteria were enrolled in this study. Twenty-five patients taking Sertrline and another twenty five patients having Clomipramine for eight weeks. Symptom improvement and side effects were monitored with clinical evaluation, Yale-Bown OCD rating scale, MSCPOR, HAMD, HAMA and TESS. Results At the end of eight weeks of treatment, there was no significant difference in the efficacy between sertraline and clomipramine. However the side effects of sertraline were lighter than clomipramine. Conclusion The results indicate that both sertraline and clomipramine is effective in the treatment of OCD, but sertraline showed more advantages for its convenient administration and the side effects of it were light.