柴胡皂甙加强氟西汀在强迫游泳模型上的抗抑郁作用

Additive Effect of Saikosaponin on the Antidepressant Action of Fluxotin in Forced Swimming Test

通过强迫游泳模型初步研究了柴胡皂甙和氟西汀的抗抑郁作用，发现4～16mg／kg柴胡皂甙不能缩短小鼠和大鼠强迫游泳不动时间，氟西汀20和40mg／kg也不能缩短小鼠和大鼠强迫游泳不动时间，80mg／kg方有作用，而亚活性浓度的氟西汀（20mg／kg）加上柴胡皂甙能缩短小鼠强迫游泳不动时间，说明柴胡皂甙单用难以起到抗抑郁作用，与氟西汀合用能加强其抗抑郁作用。

Antidepressant effect of saikosaponin and fluxotin were studied. In mice and rats forced swimming test (FST),immobility times were not reduced by 4~16mg/kg saikosaponin but were only reduced by 80mg/kg fluxotin. When saikosaponin was in combination with subactive dose of fluxotin (20mg/kg), immobility times were significantly reduced. The results suggested that saikosaponin has a synergistic effect with fluxotin as antidepressant