摘要
新合成的分子——普瑞巴林是抑制性神经递质γ-氨基丁酸（GABA）的结构衍生物。作为α2-δ亚单位配体的普瑞巴林具有镇痛、抗惊厥、抗焦虑，以及调节睡眠的功能。普瑞巴林能够与钙离子通道的α2-δ亚单位结合，导致包括谷氨酸、去甲肾上腺素、5-羟色胺、多巴胺和P物质在内的多种神经递质释放减少。本篇综述着重讨论了2005年以来普瑞巴林药理学机制以及在疼痛治疗方面的研究进展。
Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory neurotransmitter γ-aminobutyric add. It is an α2-δligand that has analgesic, anticonvulsant, anxiolytic, and sleep-modulating activities. Pregabalin binds potently to the α2-δ subunit of calcium channels, resulting in a reduction in the release of several neurotransmitters, including glutamate, noradrenaline, serotonin, dopamine, and substance P. In this review, I will discuss the pharmacology of pregabalin and available efficacy studies in pain management. This review will focus on the advances in pregabalin pharmacology since my previous review in 2005.
出处
《麻醉与镇痛》
2008年第5期25-35,共11页
Anesthesia & Analgesia
