深部脑刺激操作中蛛网膜下腔应用阿片类药物控制慢性腰背痛

在进行为时较长的深部脑刺激操作时，慢性腰背痛患者可能无法忍受手术所要求的仰卧位。许多神经生理学家在进行深部脑刺激操作过程中，严格限制应用阿片类药物和镇静药物，理由是担心在放置刺激导联时这些药物会抑制用于大脑定位的细胞放电频率。本文所述2个病例，经蛛网膜下腔给予阿片类药物，可使慢性背痛患者长时间缓解疼痛，而并未影响在大脑定位中具有关键作用的细胞放电。

Patients with chronic low bad; pain may not be able to endure the supine position required by the lengthy deep brain stimulation prooedure. Many neurophysiologists severely restrict the use of opioids and sedative drugs during deep brain stimulation procedures due to the concern for depression of cellular firing frequendes used to map the brain for placement of the stimulator leads. We present two cases in which spinal opioids were used to achieve prolonged pain relief in patients with chronic back pain, without altering cellular firing critical for brain mapping.