连萸煎剂对自发性高血压大鼠血压和心功能的影响

Influence of Lian-Yu Decoction on Blood Pressure and Cardiac Function in Spontaneous Hypertension Rats

目的:观察连萸煎剂对自发性高血压大鼠(SHR)血压和心功能的影响。方法:将24只SHR随机分为模型组(Model)、硝苯地平组(Nif)、连萸煎剂组(LY)3组,每组8只,以正常WKY大鼠为对照组(WKY)(n=8),共4组。WKY组和Model组给予生理盐水,Nif组给予硝苯地平溶液,中药组给予相应配伍剂量的浓煎剂,连续灌胃4周,用尾部加压法测量大鼠灌胃4周末尾动脉的收缩压,同时测量大鼠血流动力学及心功能指标。结果:与Model组比较,连萸煎剂组大鼠灌胃4周末血压水平均明显降低(P<0.01)。4周后心功能参数LVSP、±dp/dtmax均有明显提高,LVEDP明显降低(P<0.01或0.05)。结论:连萸煎剂能明显降低原发性高血压大鼠血压,有效改善心功能。

Objective：To observe the effects of Lian-Yu decoction on blood pressure and cardiac function in Spontaneous Hypertension Rats. Methods： 24 SHR were randomly divided into model group （Model）, nifedipine group（Nif） ,Lian-Yu decoction group, 8 normal Wky rats were used as control （WKY）, （ n = 8, in each group）. WKY and Model group were given normal saline, Nif group was given nifedipine, LY group was given Lian-Yu Oral Liquid by continuously gavages, after 4 weeks, Blood pressure and cardiac function were measured. Results： Contrast with Model group, the blood pressure was significantly decreased（ P 〈 0.01）, LVEDP was significantly decreased（ P 〈 0.01 ）, LVSP and ±dp/dtmax were increased （ P 〈 0.01 or 0.05） Conclusion： Lian-Yu decoction can significantly reduce blood pressure, and protect cardiac function in Spontaneous Hypertension Rats.