低剂量递增促排卵方案治疗多囊卵巢综合征临床效果观察

Clinical Observation on the Application of Low-dose Increasing Ovarian Stimulation in Polycystic Ovary Syndrome Treatment

目的:探讨低剂量递增促排卵方案与常规促排卵方案对体外受精-胚胎移植(IVF-ET)或卵胞浆内单精子注射(ICSI)的多囊卵巢综合征(PCOS)不孕妇女的治疗效果。方法:对2006年1月～2008年4月在本中心行IVF-ET或ICSI的PCOS不孕患者进行回顾性分析,比较采用低剂量递增方案促排卵的PCOS患者52个周期(Ⅰ组)和常规促排卵方案的PCOS患者76周期(Ⅱ组)的促性腺激素(Gn)用量、使用时间、获卵数、妊娠率、流产率及卵巢过度刺综合征(OHSS)发生率。结果:Ⅰ组Gn使用时间明显延长,获卵数和OHSS发生率减少,而Gn用量、妊娠率和流产率较Ⅱ组差异无统计学意义。结论:进行IVF-ET助孕的PCOS患者采用Gn低剂量递增促排卵方案,可在保证妊娠率的基础上,减少获卵数,预防OHSS的发生。

Objective. To evaluate the effects of low - dose increasing ovarian stimulation and conventional ovarian stimulation on the polycystic ovary syndrome （PCOS） treatment using in vitro fertilization -embryo transfer （IVF -ET） and intracyto-plasmic sperm injection （ICSI）. Methods ： The PCOS patients who received IVF - ET or ICSI from January 2006 to April 2008 were analyzed retrospectively and 128 cycles were divided into two groups. Low - dose increasing ovarian stimulation was adopted for the study group （52 cycles）, and conventional ovarian stimulation for the control group （76 cycles）. The amounts and days of gonadotropin （Gn） usage, retrieved oocyte numbers, pregnancy rates, abortion rates and incidence rates of ovarian hyperstimulation syndrome （OHSS） were compared between the two groups. Results： The days of Gn usage in the study group were longer than the control group, with the retrieved oocyte numbers and the incidence rates of OHSS lower than the control group. However, there were no statistical differences among the amounts of Gn usage, pregnancy rates and abortion rates between the two groups. Conclusion ： The application of low - dose increasing ovarian stimulation for the PCOS patients with assisted pregnancy using IVF - ET can not only ensure high pregnancy rates and low retrieved oocyte numbers, but also prevent the occurrence of OHSS.