低剂量米非司酮胶囊Ⅱ治疗复发性围绝经期功血

Low- dose mifepristone capsule Ⅱ in the treatment of recurrent blood perimenopausal

目的探讨低剂量米非司酮胶囊Ⅱ（米非司酮半固体骨架胶囊）治疗复发性围绝经期功血的效果。方法将无服米非司酮禁忌、确诊为复发性围绝经期功血的患者30例，口服米非司酮胶囊Ⅱ，5mg，每日1次，连服3个月，于治疗前后B超监测子宫内膜厚度，测血红蛋白、雌激素及肝肾功能等指标。结果患者在服药期间均闭经，治疗后随访6-12个月，9例闭经，10例月经稀发，10例恢复正常月经，1例复发。无明显副作用。结论口服低剂量米非司酮胶囊Ⅱ是较好的保守性治疗复发性固绝经期功血的治疗方法。

Objective To discuss the effect of low - dose mifepristone capsule Ⅱ in the recurrent blood perimenopausal treatment. Methods Patients who had been confirmed recurrent perimenopausal no taboos serving mifepristone with reactive blood, were asked to take mifepristone Ⅱ 5 mg capsules, once a day for 3 months. Endometrial thickness were monitored by B - monitoring before and after treatment, indicators as hemoglobin, estrogen and liver and kidney function were recorded as well. Results All the patients were amenorrhea during the medication period. In the followed - up 6 - 12 months, nine patients had amenorrhea, menstruation dilutes in 10 patients, another 10 patients resume normal menstruation, and one got recurrence. No obvious side effects. Conclusion Low - dose mifepristone capsule Ⅱ can be well used in recurrent blood perimenopausal treatment.