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融斑通脉颗粒对大鼠缺血再灌注所致心肌梗死的影响 被引量:3

Effect of Rongban Tongmai Granules on ischemia-reperfusion induced myocardial infarction in rats
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摘要 目的观察融斑通脉颗粒对大鼠缺血再灌注所致心肌梗死的影响。方法以大鼠缺血再灌注所致的心肌梗死模型,通过测定血清超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量、以硝基四氮唑蓝(N-BT)染色法测定梗死面积、梗死区重量,观察融斑通脉颗粒对心肌梗死程度的影响。结果融斑通脉颗粒组大鼠的梗死面积和梗死区重量明显低于模型组,而血清SOD活性增加、MDA含量降低。结论融斑通脉颗粒能减轻大鼠缺血再灌注所致的心肌梗死程度。 Purpose To observe the effect of Rongban Tongmai Granules on ischemia-reperfusion induced myocardial infarction in rats. Methods After establishing myocardial infarction rat models induced by ischemia-repeffusion, the infarct size, weight as well as the serum super oxide dismutase (SOD) and malonaldehyde (MDA) were measured to find out the effect of Rongban Tongmai Granules on ischemia-reperfusion induced Myocardial infarction in rats. Results Myocardial infarct size and weight were significantly smaller for rats given the treatment with Rongban Tongmai Granules than the model rats. in rats treatment with Rongban Tongmai Granules the activity of SOD was higher while the MDA was lower. Conclusion Rongban Tongmai Granules can relieve myocardial infarction induced by ischemia-repeffusion in rats.
出处 《中国生化药物杂志》 CAS CSCD 2008年第5期327-329,共3页 Chinese Journal of Biochemical Pharmaceutics
关键词 融斑通脉颗粒 心肌梗死 大鼠 Rongban Tongmai Granules myocardial infarction rats
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  • 1袁肇凯,黄献平,曹金枝,胡志希,简亚平.心肌缺血再灌注损伤大鼠冠状微循环改变的实验研究[J].中国微循环,2004,8(4):204-208. 被引量:16
  • 2杨小毅,杨永宗,谭健苗,袁中华,万载阳.一种纯系小鼠动脉粥样硬化病理模型的建立[J].中国动脉硬化杂志,1996,4(1):54-57. 被引量:27
  • 3Eisner DA,Trafford AW,Diaz ME,et al.The control of carelease from the cardiac sarcoplasmic reticulum:regulation versus autoregulation[J].Cardiovascular Research.1998,38:589~604
  • 4Derek M Yellon,Gary F Baxter,David Garado-Dorado,et al.Ischaemic preconditioning:present position and future directions[J].Cardiovascular Research.1998,37:21~33
  • 5施新猷.急性心肌缺血模型的复制[A].见:施新猷主编.医学动物实验方法[M].北京:人民卫生出版社,1986.237-238.
  • 6田牛.微循环形态学研究方法[A].见:田牛.微循环[M].北京:科学出版社,1986.8-9.
  • 7陶恭明 金惠铭 见陈文杰 田牛 赵国忠主编.荧光血管造影法及其在微循环研究中的应用[A].见陈文杰,田牛,赵国忠主编.微循环的理论和应用[M].北京:人民卫生出版社,1987.293-303.
  • 8吴其夏.体液因素和血液循环病理生理学[M].北京:北京医科大学协和医科大学联合出版社,1992.289-292.
  • 9Steurer G,Yang P,Rao V,et al.Acute myoccardial infarction,reperfusion injury,and intravenous magnesium therapy; basic concepts and clinical implications[J].Am Heart J.1996,132(2pt 2 Su):478~482
  • 10Grisgm M B,Granger D N,Lefer D J.Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen:relevance to inchemic heart disease[J].Free Radical Biol Med.1998,25(4~5):404~433

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