豫东地区铜绿假单胞菌医院感染及耐药性变迁

Hospital infection and change in antibiotic resistance of PAE in east area of Henan

目的探讨医院内铜绿假单胞菌（PAE）引起医院感染的特点，以及对抗生素的耐药性变化趋势，指导临床合理用药。方法对2005至2007年河南大学第一附属医院病房临床分离的PAE385株，用18种抗菌药物进行药敏实验。结果该菌对氯基糖甙类、头孢菌素类、碳青酶烯类、喹诺酮类药物耐药性呈逐年上升趋势。三代头孢菌素类的头孢他定耐药率30．7％，四代头孢菌素头孢吡肟的耐药率为23．4％；碳青酶烯类的亚胺培南和美罗培南的耐药率分别为22．6％和28．3％。结论对于PAE的感染，应在药敏指导下用药，适当控制三代头孢菌素类、碳青酶烯类、喹诺酮类药物的使用。

Objective To investigate the trend on hospital infection leaded by pseudomonas aeruginosa（PAE） and the resistance to antibiotics of PAE. Methods Data were collected of 385 bacteria strains isolated from clinical specimens from Jan 2005 to Dec 2007. Drug sensitivity tests were made for 18 antimicrobial agents. Results The drug resistance rate of aminoglycosides, cephalosporins, imipenem and fluoroquinolones appeared increasing trend. The drug resistance of the third generation cephalosporins was 30.7% ; cefperazone-sulbactam 23.4% , cefepime 22.6% and meropenem 28.3%. Conclusion Antimicrobial treatment with PAE should be guided by drug sensitivity test. And the usage of the third generation, cephalosporins and fluoroquinolones needs to be strategically controlled.