早产儿缺氧缺血性脑病血中血小板活化因子水平的研究

Platelet - activating factor levels of premature infants hypoxic - ischemic encephalopathy in plasma

目的研究早产儿缺氧缺血性脑病（HIE）血中血小板活化因子（PAF）水平的变化，探讨早产儿合并HIE时血中PAF水平，及PAF在早产儿HIE发病机制中的作用。方法采用ELISA方法测定早产儿HIE血中PAF水平。结果早产儿血中PAF水平（9±3）pg／ml比足月新生儿低（44±12）pg／ml；早产儿HIE时PAF浓度显著高于无HIE组，P〈0.01；早产儿轻度HIE时PAF浓度（13±6）pg／ml显著低于中、重度HIE时PAF浓度（137±59）pg/ml,P〈0．0l。结论早产儿血中PAF水平比足月新生儿低，早产儿合并轻度HIE时PAF浓度增高，中、重H／E时则明显增高。PAF在病理情况下可能参与早产儿HIE发病，并可能与HIE严重程度相关。PAF受体拮抗剂可能起到有效的神经保护作用，作为HIE的治疗提供新的途径和方法。

Objective To study the platelet - activating factor （PAF） levels in premature infants with hypoxic-ischemic encephalopathy （HIE）, and to explorethe relationship of PAF in premature infants with hypoxic - ischemic eneephalopathy （HIE）. Methods The plasma PAF from 73 premature infants and 15 healthy full - turin controls were meastured by ＂Sandwich＂ ELISA. Results The PAF levels in premature infants （9±3 ）pg/ml were lower than those in normal full-term neonates （44±12 ）pg/ml, P 〈 0.01. In premature infants, the PAF levels in mild HIE （13±6）pg/ml were significantly lower inseverity HIE （ 137±59） pg/ml and significantly higher than non-HIE （9±3） pg/ml. Conclusion Obviously higher levels of PAF in HIE indicate PAF might play an important role in pathogenesis of HIE in a special way.