高铁蛋白血症与早期血脂代谢关系的研究

Relationship Between Hyperferritinemia and Early Blood Lipid Metabolism

目的研究高铁蛋白血症与早期血脂代谢紊乱的关系。方法收集杭州市第一人民医院健康体检者382名,根据铁蛋白水平,以310ug/L为限分为高铁蛋白组(A组)与低铁蛋白组(B组);分别测定总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDLC)、载脂蛋白Al(apo A1)、载脂蛋白B(apo B),超声检查脂肪肝,对两组间的数据进行统计学分析。结果铁蛋白升高组与铁蛋白正常组相比,两组间TG、LDLC、HDLC、apo A1、apo B、脂肪肝的发生率均有显著的统计学差异(P<0.05),TG、TC、LDLC、apo B与铁蛋白间呈正相关,而HDLC、apo A1与铁蛋白呈负相关。结论铁蛋白可能是早期血脂代谢紊乱的标志物之一。

Objective To study the relationship between hyperferritinemia and early blood lipid metabolism. Methods A total of 382 physical examinees recruited from the First City People＇ s Hospital were randomly divided into two groups, the high - ferritin group （group A） and normal control group （group B） ; in the group B, the level of serum ferrifin were above and beneath 310μg/L, respectively, some indices were determined including Total cholesterol （TC）, low density lipoprotein cholesterol （LDLC）, triglyceride （TG）, high density lipoprotein cholesterol （HDLC）, apolipoprotein A1 （apo, A1） and apolipoprotein B1 （apo B1）. Fatty liver was diagnosed by ultrasonography. The data obtained were analyzed statistically. Results The levels of TG, TC, LDLC, apo A1, apo B1 and incidence rate of fatty liverin group A was significantly different from those in group B （P 〈 0.05）. There was positive correlation between the levels of ferritin and TG, TC, LDLC, apo B1, while negative correlation between the levels of ferritin and HDLC,apo A1. Conclusion The serum level of ferritin probably acts as one of the markers of early metabolic disorder of blood lipid.