200例子宫颈癌患者的HPV感染研究

The study of HPV infection in cervical cancer of 200 cases

目的：通过对200例子宫颈癌患者HPV感染及临床相关信息的分析，为宫颈癌的防治研究提供线索和依据。方法：收集200例子宫颈癌患者新鲜病灶组织，用HPV分型基因芯片检测系统对组织标本进行23种HPV亚型的分型检测。结果：HPV检出率94．00％，其中HPV16阳性率69．68％；HPV18阳性率16．49％；HPV16＋18为7．45％；HPV45为1．59％；HPV18＋33、HPV33、HPV16＋45、HPV58各1．06％；HPV73占0．53％。HPV阳性率在20—60岁以上之间划分的五个年龄段无差异（P=0．75）；HPV阳性率在按地理位置划分的五个区域之间无差异（P=0．5）；HPV阳性率在农民和无业者中明显高于干部（P〈0．025）。结论：该组资料的HPV阳性率达94．00％，且均为高危型，而HPV16是最主要的亚型。子宫颈癌与HPV关系密切，是不同年龄、不同区域。

Objective： Through the analysis of HPV infection and clinical information in 200cervical cancer, to give the clue and foundation for prevention and treatment of cervical cancer. Methods： The fresh tissues of 200 patients in our province were collected, the HPVgenotyping chip system was be used to study 23 HPV subtypes. Results： HPV infection was 94.00%, among them, HPV16 was 69.68% ; HPV18 was 16. 49% ; HPV16 ＋ 18 was 7.45% ; HPV45 was 1.59% ; HPV18 ＋ 33, 33, 16 ＋45, 58 was 1.06% respectively, HPV73 was 0. 53%. HPV positive werent difference among five age groups of 20-60 （P =0. 75） ; HPV werent difference also among five areas according to geographical position. HPV infection was higher in peasant and unprofessional than cadre （ P 〈 0. 025 ） . Conclusion ： HPV infection is very high in our data, and allare high - risk. HPV16 is the most major subtype. The relationship is close between HPV and cervical cancer, HPV is the common factor of causing cancer at varying age, geographical position, profession.