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IL-24在母胎界面的表达及其对TEV-1细胞侵袭能力的影响 被引量：2

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摘要 目的:研究IL-24在早孕期母胎界面的表达及其对绒毛外滋养细胞系TEV-1体外侵袭能力的影响。方法:免疫组化法检测早孕期绒毛及蜕膜组织中IL-24的表达情况;MTT法检测人重组IL-24蛋白对TEV-1细胞增殖的影响;用Transwell小室体外侵袭实验,分析绒毛外滋养细胞在IL-24作用下的侵袭能力。结果:早孕期绒毛及蜕膜组织均有IL-24的表达,分布于绒毛柱、滋养细胞、间质及血管内;不同浓度的人重组IL-24蛋白对TEV-1细胞增殖无影响;人重组IL-24对TEV-1细胞的侵袭能力有抑制作用,并呈一定的浓度依赖性。结论:IL-24可抑制TEV-1细胞的侵袭能力,因此早孕期母胎界面产生的IL-24可能影响滋养细胞的侵袭过程,在妊娠过程中有重要意义。
作者 程红 邹丽
机构地区 华中科技大学同济医学院附属协和医院妇产科
出处 《中国妇幼保健》 CAS 北大核心 2008年第30期4336-4338,共3页 Maternal and Child Health Care of China
基金 湖北省自然科学基金资助课题(2005ABA149)
关键词 IL-24母胎界面 IEV-1细胞系 滋养细胞 侵袭
分类号 R714.12 [医药卫生—妇产科学]
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参考文献9

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同被引文献11

  • 1Dusko Ilic, Olga Genbac. Plasma membrane- associated pY397FAK is a marker of cytotrophoblast invasion in vivo [J]. Am J Pathol, 2001, 159 (1) : 93.
  • 2Dong CY, ZHang F, Duan YJ et al. MDA -7/IL -24 inhibits the proliferation of hematopoietic malignancies in vitro and in vivo [J] . ExpHematol, 2008, 36 (8): 938.
  • 3Feng HC, Choy MY, Deng Wet al. Establishment and char- acterization of a human first - trimester extravillous trophoblast cell line (TEV- 1 ) [J]. J Soc Gynecol Investig, 2005, 12 (4): 21.
  • 4Zhao J, Guan JL. Signal transduction by focal adhesion kinase in cancer [J]. Cancer Metastasis Rev, 2009, 28 (1) : 35.
  • 5Ilic'D,Genbacev O,Jin F,et al.Plasma membrane-associated p Y397FAK is a marker of cytotrophoblast invasion in vivo and in vitro[J].Am J Pathol,2001,159(1):93-108.
  • 6Loisel DA,Billstrand C,Murray K,et al.The maternal HLA-G 1597△C null mutation is associated with increased risk of pre-eclampsia and reduced HLA-G expression during pregnancy in African-American women[J].Mol Hum Reprod,2013,19(3):144-152.
  • 7Yacoub A,Mitchell C,Lister A,et al.Melanoma differentiation-associated 7(interleukin 24)inhibits growth and enhances radiosensitivity of glioma cells in vitro and in vivo[J].Clin Cancer Res,2003,9(9):3272-3281.
  • 8Iversen AC,Nguyen OT,Tmmerdal LF,et al.The HLA-G14 bp gene polymorphism and decidual HLA-G 14 bp gene expression in pre-eclamptic and normal pregnancies[J].J Reprod Immunol,2008,78(2):158-165.
  • 9Le Bouteiller P,Fons P,Herault JP,et al.Soluble HLA-G and control of angiogenesis[J].J Reprod Immunol,2007,76(1-2):17-22.
  • 10于愿,薛新波,陈堃,郑建伟,吉文伟,王从俊.腺病毒介导的mda-7／IL-24抑制肝癌VEGF和MMP-9的表达[J].临床外科杂志,2010,18(2):95-98. 被引量：6

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中国妇幼保健
2008年 第30期

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