非酒精性脂肪肝患者血清脂联素、肿瘤坏死因子α水平的研究

Study of the level of adiponection and tumor necrosis factor α of NAFLD

目的了解非酒精性脂肪肝(NAFLD)患者血清脂连素、肿瘤坏死因子α的水平,评价其在NAFLD发生发展过程中的作用。方法选择经B超及病史诊断为NAFLD患者132例与健康体检者157例,对空腹血糖(FBG)、空腹胰岛素(FINS)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血清脂联素、肿瘤坏死因子α(TNFα)进行检测,计算胰岛素抵抗指数(HOMA-IR)并进行对照分析。结果与对照组相比,NAFLD观察组血清FBG、ALT、AST水平升高(P<0.05),FINS、TNFα及HOMA-IR明显升高(P<0.01)。血清脂联素水平明显下降(P<0.01)。血清脂联素水平与HOMA-IR、TNFα呈负相关(r值分别为-0.79,-0.61,P均<0.01)。结论NAFLD患者存在胰岛素抵抗,血清脂联素水平降低,肿瘤坏死因子α水平升高。

Objective To study the level of adiponectin and tumor necrosis factor aof patients of NAFLD.Methods 132 patients with NAFLD and 157 normal controls were choosed, Fastingblood sugar （FBG）,fasting blood imulin （FINS）,insulin resistant index（HOMA-IR）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, adiponectin and tumor necrosis factor awere detected and compared with nomal conrols. Results Compared with control group, the lever of FBG, ALT, AST increased （ P 〈 0.05） ,FINS, TNTa and HOMA-IR show the obvious difference（ P 〈 0.01 ）, and the level of adiponectin decreased obviously（ P 〈 0.01）. ThelevelofadiponectinhadnegativewithHOMA-IRandTNFa（r= -0.79,P〈O.Ol,O.61,P〈O.O1）.Condusion Insulin resistant were present in NAFLD, which had lower plasma adiponectin and higher TNFa.