败血症患者血栓调节蛋白及血小板参数的变化规律

The variation of platelet and thrombomodulin in patients with sepsis

目的观察败血症患者血栓调节蛋白、血小板、平均血小板容积、血小板容积分布宽度及大血小板比率的变化规律。方法对2006年8月至2007年6月血培养阳性者进行血栓调节蛋白、血小板及其参数的测定,并与健康体检者进行比较。结果败血症患者血栓调节蛋白、血小板及其参数与健康体检者的结果有显著性差异:TM分别为79.93±29.17μg/L和20.40±7.72μg/L,MPV分别为12.11±1.43 fl和10.98±1.01,PLT分别为172±84×109/L和212±65×109/L,P-LCR分别为41.14±11.63%和30.95±8.88%,PDW分别为15.41±3.88 fl和13.74±2.51 fl,P均<0.01。结论败血症患者血小板及血栓调节蛋白会发生质和量的变化,表示病原体感染可影响机体凝血系统的功能并损害血管内皮细胞。

Objective Study the variation of the parameters of platelets and thrombomodulin（TM） in patients with sepsis.Methods Platelets（PLT）,mean platelet volume（MPV）,platelet distribution width（PDW）and platelet-large cell ratio（P-LCR） and TM were measured of 98 patients during episodes of culture-proven sepsis,at the same time,100 health peoples served as controls.Resuits In patients with sepsis, the parameters of platelet changed significantly. The platelet count was 172±84×10^9/L in patients with sepsis and 212±65 × 10^9/L in controls, MPV wasl2.11±1.43 fl vs10.98 ±1.01fl, P-LCR was41.14±11.63 % vs 30.95±8. 88 %, PDW wasl5.41±3.88fl vs13.74 ±2.51 fl, TM were 79.93± 29.17 μg/L vs 20.40±7.72 μg/L. All P 〈 0.01. Conclusion The platelets＇ parameters and TM in patients with sepsis changed significantly, it means microorganism infection can damage the endothelial cell and play an important role in the production and consumption of the platelet in patients with sepsis.