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输卵管妊娠黏膜整合素β_1及基质金属蛋白酶-9的表达 被引量：1

Expression of integrin β_1 and MMP-9 in human oviductal mucosa during tubal pregnancy
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摘要 目的探讨整合素β1(integrin β1)和基质金属蛋白酶-9(MMP-9)与输卵管妊娠的关系。方法选择输卵管妊娠组25例、正常输卵管组27例及正常宫内早孕组28例,采用免疫组织化学染色技术及半定量病理图像分析系统检测输卵管妊娠黏膜组织、正常输卵管黏膜组织及正常宫内早孕子宫蜕膜组织中整合素β1和基质金属蛋白酶-9的表达。结果整合素β1和MMP-9在正常宫内早孕组中表达最强,在输卵管妊娠组中的表达较强,在正常输卵管组中表达较弱。三组两两比较差异均有统计学意义(P<0.05)。结论整合素β1和MMP-9都参与了输卵管妊娠的过程。 Objective To explore the relationship between integrin β1 and matrix metalloproteinase-9（MMP-9） and tubal pregnancy. Methods Expression of integrin β1 and MMP-9 in oviductal mucosa in tubal pregnancy group（ n = 25） and normal oviduct group（ n = 27）, and decidua tissues in early pregnant group（ n = 28） was detected by immunohistochemistry, and the data were analyzed by semi-quantity pathologic image analysis. Results The positive expression of integrin β1 and MMP-9 in tubal pregnancy group was significantly stronger than that in normal oviduct group, but weaker than that in early pregnant group （ P 〈 0.05）. Condusion Integrin β1 and MMP-9 may take part in the tubal pregnancy.
作者 晏长荣 李斌 邓成国
机构地区 郧阳医学院组织学与胚胎学教研室 郧阳医学院病理学教研室
出处 《山西医科大学学报》 CAS 2008年第10期892-894,960,F0003,共5页 Journal of Shanxi Medical University
基金 郧阳医学院研究生启动基金资助项目(2006QDJ11)
关键词 输卵管妊娠 整合素Β1 基质金属蛋白酶-9 tubal pregnancy integrin β1 matrix metalloproteinase-9
分类号 R714.22 [医药卫生—妇产科学]
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参考文献6

  • 1曹泽毅.中华妇产科学[M].2版.北京:人民卫生出版社,2004:29.
  • 2Sulz L, Valenzula J P, Salvatierra AM, et al. The expression of αvβ3 integrin subunits in the normal human fallopian tube epithelium suggests the occurrence of a tubal implantation window[J ]. Hum Reprod, 1998,13 ( 10 ) : 2916 - 2920.
  • 3Laquerriere P, Grandjean-Laquerriere A, Addadi-Rebbah S, et al. MMP-2,MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles[J]. Biornaterials,2004,25(13) : 2515 - 2524.
  • 4Young KA, Hennebold JD, Stouffer RL. Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors luteum in the primate corpus luteum during the menstrual cycle[ J ]. Mol Hum Reprod, 2002,8 (9) : 833 - 840.
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  • 6刘雪梅,钟刚.基质金属蛋白酶及其抑制物与子宫内膜[J].国外医学（计划生育分册）,2005,24(4):175-178. 被引量：7

二级参考文献20

  • 1Laquerriere P, Grandjean-Laquerriere A, Addadi-Rebbah S, et al MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles. Biomaterials, 2004, 25(13):2515-2524.
  • 2Young KA, Hennebold JD, Stouffer RL. Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors luteum in the primate corpus luteum during the menstrual cycle. Mol Hum Reprod, 2002,8(9): 833-840.
  • 3Koks CA, Groothuis PG, Slaats P, et al. Matrix metalloproteinases and their tissue inhibitors in antegradely shed menstruum and peritoneal fluid. Fertil Steril, 2000, 73(3): 604-612.
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  • 5Galant C, Berliere M, Dubois D, et al. Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding. Am J Pathol, 2004, 165(1):83-94.
  • 6Comet PB, Galant C, Eeckhout Y, et al. Regulation of matrix metalloproteinase-9/gelatinase B expression and activation by ovarian steroids and LEFTY-A/EBAF in the human endometrium. J Clin Endocrinol Metab, 2005, 90(2):1001-1011.
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  • 10Castellucci M, De Matteis R, Meisser A, et al. Leptin modulates extracellular matrix molecules and metalloprotinases: possible implications for trophoblast invasion. Mol Hum Reprod, 2000, 6(10): 951-958.

共引文献236

同被引文献5

  • 1刘雪梅,钟刚.基质金属蛋白酶及其抑制物与子宫内膜[J].国外医学（计划生育分册）,2005,24(4):175-178. 被引量：7
  • 2Laquerriere P, Grandjean-Laquerriere A, Addadi-Rebbah S, et al. MMP-2, MMP-9 and their inhibitors TIMP-2 and TIMP-1 production by human monocytes in vitro in the presence of different forms of hydroxyapatite particles [ J ]. Biomaterials, 2004,25 ( 13 ) : 2515 - 2524.
  • 3Young KA, Hennebold JD, Stouffer RL. Dynamic expression of mRNAs and proteins for matrix metalloproteinases and their tissue inhibitors in the primate corpus luteum during the menstrual cycle [ J ]. Mol Hum Reprod ,2002,8 ( 9 ) : 833 - 840.
  • 4Lanone S, Zheng T, Zhu Z, et al. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13 induced inflammation and remodeling [ J ]. J Clin Invest, 2000,110 (4) :463 -474.
  • 5梁琴,李红发.金属基质蛋白酶(MMP-2)及其激动剂和抑制剂在输卵管黏膜上皮的表达与输卵管妊娠的关系[J].生殖与避孕,2008,28(9):530-534. 被引量：3

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山西医科大学学报
2008年 第10期

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