抑郁症早醒严重程度与血清皮质醇关系的初步探讨

A preliminary study on relationship between early awaking and serun cortisoi in depression disorder

目的探讨抑郁症患者早醒症状的生物学基础。方法用放射免疫法测定59例抑郁症患者早晨血清皮质醇水平，并评估抑郁症患者早醒时间。结果1．早醒组较非早醒组早晨血清皮质醇水平明显增高[（377．32±14．54）μm／L；（324．15±16．44）μm/L，P〈0．05]。2．早醒时间与早晨血清皮质醇水平呈显著正相关（r=0．353，P=0．006）。3．早醒时间与早晨血清皮质醇水平有直线关系（β=0．006，P=0．006）。结论抑郁症早晨血清皮质醇水平升高可能参与了抑郁症早醒症状的出现。

Objective To explore biological elements of early awaking in depression. Methods The plasma concentration of cortisol was measured by immunoradioassay in the morning in 59 depressive patients, and how many hours the depressive patients awake earlier than normal was evaluated. Results The plasma concentration of cortisol in the morning of early awaking group was higher than no early awaking group[ （377.32 ± 14.54 ） μm/L vs （324.15 ± 16.44）μm/L, P 〈 0.05 ] There was rectilinear correlation between the hours that the patients awake earlier than normal and the plasma concentration of cortisol in the morning（r = 0. 353, P = 0. 006, n = 59）. There was linear regression between the hours that the patients awake earlier than normal and the plasma concentration of cortisol in the morning（β = 0. 006, P = 0. 006, n = 59 ）. Conclusion The high plasma concentration of cortisol in the morning probably leads to early awaking in depression.