静脉用丙种球蛋白治疗儿童过敏性紫癜疗效观察

Clinical Application of IVIG in Treatment of Henoch-Schonlein Purpura in Children

目的探讨静脉用丙种球蛋白(MG)对小儿过敏性紫癜的治疗效果。方法将58例混合型过敏性紫癜患儿随机分成丙球治疗组28例、激素治疗组30例,另设常规对照组40例,观察皮疹、关节症状、腹痛消失时间及3个月内肾损情况,并对结果进行统计学分析。结果①丙球治疗组在皮疹、腹痛、关节症状消失时间及住院时间均显著短于常规对照组(P<0.01);②丙球治疗组与激素治疗组相比,在皮疹消退及住院天数上差异有统计学意义(P<0.01)。③治疗3个月后,丙球治疗组肾损害的发生率明显低于另外两组(P<0.01)。结论MG对过敏性紫癜疗效满意。

Objective To evaluate the effectiveness of IVIG in treating Henoch - Schonlein purpura of children.Methods A total of 58 patients with Henoch - Schonlein purpura were randomly divided into 2 groups. The first group were administrated WIG, the second group were administrated Methylprednisolone, while other 4 ＋ 0 patients who received the routine treatment as comparison group. Extinction time of rash, joint symptom, abdominal pain and kidney lesion during three - month treatment were observed and analyzed. Results （1） IVIG group was significantly shorter than conventional therapy group in extinction time of rash, joint symptom, abdominal pain and length of stay（all P 〈 0.01）;（2） Comparing IVIG group with corticoid group respectively, significant difference in extinction time of rash and length of stay were found（both P 〈 0.01 ） ;Using gammaglobulin, rash disappeared faster and length of stay reduced significantly. （3）The incidence of kidney lesion of IVIG group was significantlyshorter than the other two groups after three- month treatment（both P 〈 0.01 ）. Conclusion IVIG has evidently effect on treating HSP.