心得安联合安体舒通预防肝硬化门脉高压性再出血的研究

Investigation of propranolol combined with antisterone for the prevention of portal hypertensive rebleeding associated with liver cirrhosis

目的:探讨心得安联合安体舒通预防肝硬化门脉高压性再出血的疗效,不良反应及其作用机制。方法:将106例肝硬化门脉高压出血患者随机分为三组:心得安加安体舒通组(A组);心得安组(B组);对照组(C组)。在临床上对三组患者进行前瞻性对照研究,观察其疗效。结果:随访2年,A组12个月、18个月、24个月再出血率及死亡率均显著低于B组与C组,差异具有显著性(P<0.05)。临床上未见明显不良反应。结论:心得安联合安体舒通预防肝硬化门脉高压性再出血安全有效,值得临床推广。

Objective ：To investigate the efficacy of propranolol combined with antisterone for the prevention of portal hypertensive rebleeding associated with liver eirrhosis, and its adverse reaction and mechanism. Methods ：106 patienes with portal hypertensive bleeding associated with liver cirrhosis were randomly divided into three groups：propranolol plus antisterone group （group A）;propranolol group （group B） and control group （group C）.Three groups were reseached prospectively and comparatively.And their therapeutic effeets were observed. Results：Following two years, the rebleeding rate in 12 months, 18 months,24 months and mortality after treatment in group A were signifieantly lower than group B and group C（P〈0.05）,without adverse effects.Conclusion：Propranolol combined with antiserone is a safe and effective therapy in preventing the portal hypertensive rebleeding assoeiaeeel with liver eirrhosie, and worth further generalization.