^(131)I 碘化油在阻断左肝静脉时动脉栓塞的动物实验研究

Experimental study of hepatic arterial embolization with 131I-lipiodol in temporary occlusion of the left hepatic vein

用１３１Ｉ标记碘化油作为肝动脉栓塞剂，对小猪行左肝静脉阻断下左肝动脉栓塞。１３１Ｉ碘化油标记用交换催化反应法，标记率在９５％以上。术后定期作ＳＰＥＣＴ显像，通过图像了解肺／肝放射性计数比、全身放射性分布情况及核素体内衰变规律和病理变化。结果是肺／肝放射性计数比值于术后第１、３天明显降低，差别显著（Ｐ＜０．０５）。而术后第５、７、１４天的比值，两组之间无明显差别（Ｐ＞０．０５）。１３１Ｉ－碘化油体内有效半衰期４．５３天（中位数）。病理学检查，肝脏见散在斑点状小梗死灶，部分左叶包膜较增厚。镜下油栓处梗死灶凝固性坏死，纤维化改变。结果表明，暂时性阻断左肝静脉下行肝动脉１３１Ｉ碘化油栓塞，通过对肝血流动力学及肝内油栓分布的影响可提高栓塞效果，同时对急性肺栓塞也有一定的预防作用。

fter temporary occlusion of left hepatic vein, hepatic arterial embolization (HAE) were performed with 131 I-lipiodol, it can improve the effectiveness of HAE in treatment of hepatocillular carcinoma Using the pig as a model, during the course of embolization of the left hepatic artery with 131I-lipiodol, temporary occlusion of the left hepatic vein was done in the experimental group Lipiodol was labelled with 131I using exchanged reaction method The labelled rate was 95% The lung/liver radioactive ratio, radioactive distribution and the condition of radioactive decay in body was obtained by the SPECT imaging after operation The radioactive ratio of the lung/liver in experimental group was lower than that in control group (<005) on the 1st and 3rd days after operation and has no significant difference on the 5th, 7th and 14th days (<005) The effective half-life of 131I-lipiodol was 453 day (median) The pathological change of experimental group was more severe than control group expressing spotty infarct, fibrinoid necrosis, coagulation necrosis etc The result of experiment showed that this method is safe, effective and can tentatively be used clinically