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食管癌组织中mdm2基因表达的意义 被引量:3

Significance of mdm2 gene expression in the esophageal carcinoma
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摘要 目的:了解mdm2基因在人食管癌基因中的表达情况。方法:应用免疫组化SP法检测58例食管癌及癌旁正常组织中mdm2基因蛋白的表达。结果:食管癌组织中mdm2蛋白阳性率为63.8%,高于mdm2癌旁正常组织mdm2的表达(35.0%),P<0.05;mdm2蛋白的表达与淋巴结转移和病理分级有相关性,而与性别和浸润深度无关。结论:mdm2蛋白的异常表达与食管癌的发生、发展有关,可作为诊断、判断预后的辅助指标。 Objective: To study the role of mdm2 gene expression in human esophageal carcinoma. Methods: The gene expressions of mdm2 in the esophageal were detected using immunohistochemistry SP respectively. geal carcinoma and its adjacent normal tissue were 63.8% carcinoma and its adjacent normal tissue of 58 patients Results: The positive rate of mdm2 protein in esopha- and 35.0% respectively; there was significant difference between them(P〈 0.05 ) ; the expression of mdm2 protein was related to the lymphatic metastasis and the grade of carcinoma; it did not relate to gender and depth of infiltration. Conclusion: The abnormal expression of mdm2 protein relates to the genesis of esophageal carcinoma and progress, it may serve as an reference indicator for the diagnosis and prognosis.
作者 黄永高
出处 《海南医学院学报》 CAS 2008年第6期642-643,共2页 Journal of Hainan Medical University
关键词 食管肿瘤 MDM2基因 免疫组化 Esophageal cancer Mdm2 gene Immunohistochemistry
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  • 1Tandon S, Beer H, Jones TM, et al . Immunohistochemical expression of p53 and MDM2 within head and neck squamous cell carcinoma [ J ]. Clin Otolaryngol, 2006,31 (3):247.
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