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克罗恩病的预报指标及其应用意义

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摘要 克罗恩病（Crohn＇s disease，CD）是一种致残性肠道疾病，其致残的原因主要是肠道慢性炎症、频繁的临床复发、肠内外并发症，以及肠切除带来的不良后果等。传统应用的由轻到重顺序调整药物的逐步升级治疗方式，并不能有效地控制炎症活动而使病变愈合.
作者 郑家驹 张明
机构地区 江苏省苏州市立医院消化科 南京大学附属鼓楼医院
出处 《医学新知》 CAS 2008年第5期262-263,共2页 New Medicine
关键词 克罗恩病 预报
分类号 R574.62 [医药卫生—消化系统]
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参考文献8

  • 1Beaugerie L, Seksik P, Nion-larmurier I, et al. Predictors of Crohn's disease[J]. Gastroenterol,2006,130(3):650-656.
  • 2Oostenbrug L E, van Dullemen H M, te Meerman G J, et al. Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease course [J]. Eur J Gastroenterol Hepatol,2006,18(3):255-261.
  • 3Munkholm P, Langholz E, Davidsen M, et al.Frequency of glucocorticoid resistance and dependency in Crohn's disease[J]. Gut,1994,35:360-362.
  • 4Giaffer M H, Clark A, Holdsworth C D. Antibodies to Saccharomyces cerevisiae in patients with Crohn's disease and their possible pathogenic importance[J]. Gut. 1992.33(8): 1071-1075.
  • 5庞智,皇甫照,郑家驹.抗酿酒酵母菌和中性粒细胞胞浆抗体联合测定鉴别炎症性肠病的意义[J].中华消化杂志,2004,24(12):745-747. 被引量：10
  • 6Zholudev A, Zurakowski D, Young W, et al. Serologic testing with ANCA, ASCA, and anti-OmpC in children and young adults with Crohn's disease and ulcerative colitis: diagnostic value and correlation with disease phenotype [J]. Am J Gastroenterol,2004,99(11):2235-2241.
  • 7Vasiliauskas E A, Kam L Y, Karp L C, et al. Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics[J]. Gut,2000,47(4):487-496.
  • 8Kim B C, Park S, Han J, et al. Clinical significance of anti-Saccharomyces cerevisiae antibody (ASCA) in Korean patients with Crohn's disease and its relationship to the disease clinical course[J], Dig Liver Dis,2007,39 (7):610-616.

二级参考文献7

  • 1Shanahan F. Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics. Gastroenterology, 2001,120:622-635.
  • 2Tibble JA, Sigthorsson G, Bridger S, et al. Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease. Gastroenterology, 2000,119:15-22.
  • 3Peeters M, Joossens S, Vermeire S, et al. Diagnostic value of antisaccharomyces cerevisiae and antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease. Am J Gastroenterol, 2001,96: 730-734.
  • 4Nielsen OH, Vainer B, Madsen SM, et al. Established and emerging biological activity markers of inflammatory bowel disease. Am J Gastroenterol, 2000,95: 359-367.
  • 5Walker LJ, Aldhous MC, Drummond HE, et al. Anti-saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease are associated with disease severity but not NOD2/CARD15 mutations.Clin Exp Immunol, 2004,135:490-496.
  • 6Sutton CL, Yang H, Li Z, et al. Familial expression of anti-saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut, 2000, 46: 58-63.
  • 7Vermeire S, Joossens S, Peeters M, et al. Commparative study of ASCA (anti-saccharomyces cerevisiae antibody) assays in inflammatory bowel disease. Gastroenterology, 2001,120: 827-833.

共引文献9

医学新知
2008年 第5期

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