原发性高血压血瘀证患者动态血压变化特点的临床研究

Clinical Study on Characteristics of Changes in Dynamic Blood Pressure in Patients with Primary Hypertension of Blood Stasis Syndrome

目的:观察原发性高血压血瘀证患者动态血压变化的特点。方法:将60例原发性高血压患者随机分为高血压血瘀证组与非血瘀证组,同时设体检健康人群30例作为正常对照组。所有患者均使用无创携带式全自动监测仪监测动态血压,观察患者动态血压的变异性及昼夜变化节律,同时检测血脂,肝、肾功能指标。结果:高血压血瘀证组与非血瘀证组患者动态收缩压的变异性明显高于正常对照组(P<0.05,P<0.01);高血压血瘀证组患者动态收缩压的变异性明显高于非血瘀证组(P<0.05),动态舒张压的变异性明显高于对照组(P<0.01)。高血压非血瘀证组以杓型高血压为主,血瘀证组以非杓型为主。高血压组血脂,肝、肾功能指标与正常对照组比较,无显著性差异。结论:原发性高血压血瘀证患者存在着明显动态血压变异及昼夜节律的改变,动态血压变异及昼夜节律的改变可能是高血压血瘀证微观辨证的指标之一。

Objective：To observe the characteristics of the changes in dynamic blood pressure in patients with primary hypertension of blood stasis syndrome（BSS）. Methods：60 cases of primary hypertension were randomized into BSS group and non-BSS group. Simultaneously, 30 cases of health group were set up as normal control group. Dynamic blood pressure was monitored with non-invasive portable automatic monitor for all of the cases. It was to observe variability of dynamic blood pressure and alternative circadian rhythm, as well as blood lipid and indexes of liver and kidney functions. Results： The variability of dynamic systolic pressure in BSS and non-BSS groups was higher apparently than that in normal control group（P〈0.05 ,P〈0.01 ）. The variability of dynamic systolic pressure in BSS group was higher apparently than that in non- BSS group （P〈0.05）, and the variability of its dynamic diastolic pressure was higher apparently than that in control group （P〈0.01）. Dipper pressure was predominated in non-BSS group and Non-dipper pressure was in BSS group. Significant differences did not presented in blood lipid and indexes of liver and kidney functions in comparison between hypertension groups and normal control group. Conclusion：Primary hypertension of blood stasis syndrome presents apparent alternations in variability of dynamic blood pressure and circadian rhythm which may be one of the indexes in micro differentiation for hypertension of blood stasis syndrome.