292例女性泌尿生殖道支原体、衣原体感染监测及耐药敏分析

Detection of mycoplasma and chlamydia in 292 cases of female urogenital tract Infections and the antibiotic susceptibility analysis

目的监测沙眼衣原体(CT)、解脲支原体(UU)感染发生率,分析其对抗菌药物的敏感及耐药性,用以指导临床治疗。方法CT采用Unipath有限公司生产的沙眼衣原体检测试剂盒(免疫层析法),UU采用珠海市银科生物技术应用研究所生产的支原体分离鉴别培养和药敏试剂盒。结果292例泌尿生殖道感染患者宫颈分泌物样本中检出CT37例,阳性率为12.7%;UU171例,阳性率为58.6%。其中19例患者为UU+CT混合感染。大环内酯类除罗红霉素外均有较高的敏感性,而喹诺酮类除司帕沙星(敏感性为55.0%)外均表现出较高的耐药性。结论支原体对抗菌素的耐药性,尤其是多重耐药性增加。临床医师在该类疾病治疗中,应尽量参照药敏试验,选用敏感的抗菌药物,进行正规治疗。

Objective To assess the antibiotic susceptibility and resistance of female urogenital chlamydia trachomatis（CT）and urealplasma urealyticum（UU）,isolated from endocervical swabs of 292 outpatients;And consequently,to search for a better way of clinical treatments of these patients.Methods Both UU and CT were isolated and identified using commercially available kits.The antibiotic susceptibility test for the urogenita urealplasma urealyticum was also carried out.Results of 292 patients,37（12.7%）were positive to CT,and 171（58.6%）were positive to UU,including 19 were positive to both UU and CT.Therefore,it appears that macrolides showed a susceptibility to UU to a higher degree in the present study.However,most quinolones showed a resistance to UU.Conclusion We suggest that the antibiotic administration to patients with mycoplasma infections should be well controlled.The rational treatment should be based on culture isolation and the in vitro determination of the antibiotic susceptibility of urogenita mycoplasma in each clinical case.