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电泳微芯片进样口与微沟道形状的优化设计

Optimized design about microchannel shape of sample injection on microchip electrophoresis
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摘要 基于电渗流场的理论,建立电泳芯片的不同结构模型,以计算流体力学(CFD)方法来模拟不同设计参数和电压组合下的电泳微芯片微沟道中流体流动现象。最终优化基本型毛细管微沟道交叉口形状为矩形,微沟道宽度为20μm,进样与分离场强为200-250V/cm。为在有限芯片面积下增加有效分离距离,设计螺旋形沟道电泳芯片模式。 Based on the theory of electroosmosis flow, the different structure models of microchip electrophoresis are set up, and the fluid flow situation in the microehannel are simulated with, the CFD software at the different design parameter and the ,voltage combination. The final simulation results indicate that the shape of sample injection on the microchip electrophoresis is the rectangle, the width of the microchannel is 20μm, the electric field strength Of the sample injection and separation is between 200 -250 V/cm. Also a kind of spiral microchannel mode is optimized with the better separation efference in order to increase the efficiency separation distance on the limited microchip area,
出处 《传感器与微系统》 CSCD 北大核心 2008年第10期82-85,共4页 Transducer and Microsystem Technologies
关键词 电泳微芯片 计算流体力学 电渗流 微沟道 microchip electrophoresis CFD electroosmosis microchannel
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  • 1田丽,陈伟平,刘晓为,王喜莲.毛细管电泳芯片分离DNA片段的实验研究[J].哈尔滨工业大学学报,2004,36(8):1020-1022. 被引量:3
  • 2Bier M, Palusinski R A, Mosher R A et al. Science,1983,219:1281.
  • 3Andreev V P, Lisin E E. Chromatogr, 1993, 37:202.
  • 4Fan Z H, Harrison D J. Anal Chem, 1994,66:177.
  • 5Effenhauser C S, Manz A, Widmer H M. Anal Chem,1993,65: 2637.
  • 6Tian L,Wang W,Chen W,P,Liu X,W,Bao Zh,Y,A Novel Integrated Capillary Electrophoresis Chip with a Self-rinsing Micromump[C]//. ICMIT2005, 重庆.
  • 7Stephen C. Jacobson, Roland Hergenroder, Lance B. Koutny, et al. Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices[J]. Anal.Chem. 1994(66) : 1107-1113
  • 8Yu C, Svec F, Frechet J M, Towards Stationary Phases for Chromatography on A Microchip [J ], Electrophoresis, 2000(21):120-127
  • 9Neelesh A. Patankar, Howard H. Hu. Numerical Simulation of Electroosmotic Flow[J]. Anal. Chem. 1998,70:1871
  • 10熊少祥,韩慧婉,赵睿,王光辉,马会民,陈义,刘国诠.高效毛细管电泳-激光诱导荧光检测生物活性肽的研究[J].分析测试学报,1999,18(5):1-4. 被引量:11

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