帕罗西汀联合心理干预治疗脑卒中后抑郁的疗效观察

Effect of Paroxetine Combined with Psychotherapy in the Treatment of Patients with Post-stroke Depression

【目的】观察抗抑郁药物帕罗西汀联合心理干预对脑卒中后抑郁的疗效。【方法】96例卒中后抑郁症患者随机分为治疗组和对照组各48例,两组均给予帕罗西汀20mg/d晨服;治疗组同时采用心理治疗。治疗前后8周末分别用汉密尔顿抑郁量表(HAMD)、中国卒中量表(CSS)评定其疗效。【结果】治疗8周后,两组的HAMD、CSS评分均明显低于治疗前,且治疗组均优于对照组,差异均有显著性(P<0.01)。治疗组抑郁总有效率、神经功能恢复总有效率均为93.7%,明显高于对照组的77.1%和79.2%(P<0.01)。【结论】帕罗西汀联合心理干预有良好的抗抑郁及促进神经功能恢复的作用,疗效优于单纯药物治疗。

[Objective] To study the effects of Paroxetine combined with psychotherapy m treating post-stroke depression. [Methods] In this study, a total of 96 patients with post-stroke depression were divided into 2 groups randomly. Among all patients, 48 patients were treated with Paroxetine （Control group） and other 48 patients were treated with Paroxetine combined with psychotherapy （Treatment group） for 8 weeks. HAMD and CSS were used to evaluate the symptoms improvement and side effects. [Results] After 8 weeks treatment, HAMD and CSS scores obviously decreased in two groups, but these scores in the treatment group were lower than those in the control group. There were significant differences in two groups （P〈0.01）. The total rate of effectual remedy for anti-depression and recovery neurological function were obviously higher in treatment group （93.7%, 93.7%） than those in control group （77.15%, 79.2%）. [Conclusion] Paroxctine combined with psychotherapy can obviously improve anti-depression and recovery degree of neurological function.