摘要
为探讨性激素对鼠实验性肝癌的影响，复制DEN－AAF－PH肝癌动物模型．从形态计量角度．分别观察雌二醇、睾酮和去势手术对鼠实验性肝癌的作用。结果表明，雄性大鼠比雌性形成癌前增生性结节的数目多，体积大（P＜0．01）；雌二醇可使结书数目减少和体积减小．而睾酮与之相反；睾丸切除可减轻癌前病变．卵巢切除可加重癌前增生性结节的病变程度。性激素在鼠实验性肝癌的发生发展过程中起着重要作用。
To investigate the effects of sex hormone on experimental HCC in rats, HCC model wasreconstructed by DEN-AAF-PH method. The effects of estradiol, testosterone and castration wereobserved and analysed by morphometry. The results indicated that the number and volume of precancerous hyperplastic nodules were larger (P<0. 001) in male than in female rats; cstradiol reduced thenumber and size of nodules, while testosterone increased them; orchiectomy could lighten the precancerous pathological change but ovariectomy could worsen it. Sex hormones might play some importantroles in the occurrence and development of experimental HCC in rats.
出处
《泸州医学院学报》
1997年第3期188-192,共5页
Journal of Luzhou Medical College
关键词
肝肿瘤
癌前病变
性激素
形态计量
Sex hormone
HCC
Animal model
Precancerous pathological change
Morphometry
