硬膜外腔复合液注射对兔的病理学影响

Pathology influence of epidural space composition liquid injected on rabbits

目的观察硬膜外腔复合液注射对兔硬膜外腔、脊髓和神经根组织病理学的影响。方法用硬膜外腔注射法,将3种不同复合液分别注入兔的硬膜外腔,连续给药4周、8周后,取兔腰骶部组织和脊髓、神经根标本,处理切片后在电镜下进行观察。结果硬膜外腔给药后4周、8周,3组动物与正常对照组相比,组织病理有改变。结论硬膜外腔复合液注射后,兔硬膜外腔、脊髓、神经根周围的组织病理学产生了变化,但脊髓和神经根未发生器质性改变。

Objective It is to observe the influence of epidural space composition liquid injected on histopathology of epidural space, spinal cord and nerve root in rabbits. Methods Three kinds of different composition liquid were respectively injected in epidural space of rabbits with epidural space injection method. After successive medication for four weeks and eight weeks, the specimens of lumbosacral region tissue, spinal cord and nerve root in rabbits were taken out and made into slicing. Then the specimens were observed under electron microscope. Results After epidural space medication for four weeks and eight weeks, the histopathology in the three groups had changes compared with that in normal control group. Conclusion After epidural space composition liquid injected, the peripheral histopathology of epidural space, spinal cord and nerve root in rab- bits have changes, but spinal cord and nerve root have no organic changes.