支气管哮喘患儿治疗前后血清IL-6、IL-10和GM-CSF检测的临床意义

Clinical Significance of Determination of Changes of Serum IL-6,IL-10 and GM-CSF Levels After Treatment in Pediatric Patients with Bronchial Asthma

目的:探索了支气管哮喘患儿治疗前后血清IL-6、IL-10和GM-CSF水平的变化及临床意义。方法:应用放射免疫分析对33例支气管哮喘患儿进行了治疗前后血清IL-6、IL-10和GM-CSF测定,并与30名正常健康儿作比较。结果:支气管哮喘患儿在治疗前后血清IL-6、IL-10和GM-CSF水平均非常显著地高于正常儿(P<0.01),经治疗三个月后则与正常儿组比较无显著性差异(P>0.05)。结论:检测血清IL-6、IL-10和GM-CSF水平变化对支气管哮喘患儿的治疗、预后均具有重要的临床价值。

Objective To explore the changes of Serum IL-6, IL-10 and GM-CSF levels after treatment in pediatric patients with bronchial asthma. Methods Serum IL-6, IL-10 and GM-CSF levels were measured with RIA in 33 pediatric patients with bronchial asthma both before and after treatment as well as in 30 controls. Results Before treatment, the serum IL-6, IL-10 and GM-CSF levels were significantly higher than those in controls （P〈0.01）. After 3 months treatment, the levels were not significantly different from those in controls （P〉0.05）. Conclusion Detection of serum IL-6, IL-10 and GM-CSF levels were useful for assessment of therapeutic efficacy and were of important clinical values in pediatric patients with bronchial asthma.