中药大黄治疗障碍性不完全胸腰髓损伤的临床研究

The therapeutic effects of Rhubarb in 21 patients with ISCI-IUFD

目的观察中药大黄对外伤后首发大小便障碍的不完全胸腰髓损伤（ISCI-IUFD）病例治疗效果。方法对21例首发合并大小便障碍并在12-24h内出现不完全胸腰髓损伤病例,11例应用中药大黄进行治疗,10例进行常规治疗。用体感诱发电位（SEPs）进行监测,观察治疗前后SEPs的变化、膀胱残余尿和排尿阻力情况。比较其损伤后运动分级。结果经6个月随访,中药大黄治疗组11例完全恢复,常规治疗组10例有7例完全恢复,3例恢复至D级。所有病例体感诱发电位潜伏期均有不同程度的延长,波幅均有不同程度的下降,经常规治疗后SEPs都恢复至较为正常的情况,同时膀胱残余尿和排尿阻力也恢复至接近正常水平。结论中药大黄对不完全胸腰髓损伤合并大小便障碍具有良好的治疗作用。

Objective To observe the therapeutic effects of Rhubarb treatment of the incomplete spinal cord injury with incontinence urinary and fecal discharge （ISCI-IUFD）. Methods 21 patients had the first symptom of the incontinence urinary and fecal discharge and within 12-24 h they occurred the incomplete spinal cord injury, 11 cases observed with Rhubarb, observed the change of SEPs, the bladder residual urine and resistance of micturatc. Compared the grade of the injury. Results After 6 month＇s track, 11 patients of the Rhubarb group all recovered entirely, 6 of 10 patients of routine treatment group recovered, and 3 patients recovered D grade from B. In some extent, latent period of SEPs of all patients were prolonged, amplitude of SEPs were declined. SEPs approach to the normal level after therapy, the bladder residual urine and resistance of micturate also came to normal. Conclusion Rhubarb has well therapeutic effects on the treatment to the ISCI-IUFD.