35例老年人肝细胞癌临床病理及预后特点分析

Analysis of clinicopathological and prognostic features of 35 elderly patients with hepatocellular carcinoma

目的探讨老年人肝细胞癌的临床病理及预后的特点。方法回顾性分析2001年1月至2005年1月手术治疗肝细胞癌的35例老年人患者和同期159例非老年人患者的临床病理资料，比较两组在临床病理特点和术后累积生存率的差异。结果老年人组1、2．3年累积生存率分别为80．0％、62．1％和50．4％，非老年人组分别为81．7％、65．4％和50．6％，两组差异无统计学意义（P=0．578）。但患者术前ALB浓度较低、术前ALT和ALP浓度较高、术前肝功能Child-Pugh分级为B级者多见、肿瘤病灶数目为1个者多见（P〈0．05）。结论老年人组与非老年人组之间在术前肝功能状况和肿瘤病灶数目方面有一定的差异，但两组手术治疗疗效基本相似。

Objective To explore the clinicopathological and prognostic features of elderly patients with hepatoeellular carcinoma（HCC）. Methods The clinical and pathologic data of 35 elderly and 159 nonelderly patients receiving hepateetomy because of HCC from January 2001 to January 2005 were retrospectively analyzed. Clinicopathological features and post-surgical survival rates were compared between them. Results The post-surgical cumulative survival rate of 1,2 and 3 years in elderly with HCC group was 80% ,62. 1% and 50.4% ,respectively. In non-elderly group it was 81.7% ,65. 4% and 50. 6% ,respectively. No significant difference was found in post-surgical cumulative survival rate between, them. Compared with non-elderly group, the elderly had lower preoperative ALB level, higher preoperative ALT and ALP level. Cases of that preoperative liver function Child-Pugh grades was B and number of tumor nodules was one in the elderly group were more than the non-elderly （ P 〈 0. 05 ）. Conclusion There are some differences in preoperative liver function condition and number of tumor nodules between elderly and non-elderly patients with HCC, but the post-surgical therapeutic effect is similar on the whole between two groups.