骨性关节炎诱导性动物模型研究进展

Research development of the induced animal model of osteoarthritis

骨性关节炎(osteoarthritis,OA)是一种随年龄增长而发生率明显增加的退行性关节疾病,随着社会人口的老龄化,该病发病率呈显著上升趋势。其病因及发病机制目前仍不是十分清楚,因此通过建立OA动物模型来探讨其病理机制并寻找合理有效的诊疗手段成为研究OA的重要方法,而诱导性动物模型又是其中较常用的一种,它包括非手术方法和手术方法两种。非手术方法主要有药物注入、关节制动、关节撞击等,手术方法主要有破坏关节稳定性、改变关节应力、关节刻痕等。该文就以上内容作一简要综述,以期能为正确合理地选择骨性关节炎动物模型提供一定的参考。

Osteoarthritis （OA）is a retrogressive arthrosis of which incidence rate increased obviously with the age. Accompany with the aging of the population, the incidence of this disease appeares an upward trend significantly. The etiology and pathogenesis of AO is not very clear at present, so it＇s important to establish animal models for discussing the pathogenesis of AO and searching reasonable ways to diagnose and treat. The induced animal model is used more commonly,it includes nonoperation ways and operation ways, the former includes drug injection ,joint immobilization, transarticular impact, etc. ;the latter includes destroy the stability of joint, change the stress of joint, snick on condylofemur etc. This article makes a brief review on those questions ,looks forward to providing some reference on choosing OA animal model correctly and reasonably.