肝癌相关基因及相互作用的研究进展

Advances in genes and gene interaction of hepatocellular carcinoma

肝癌的发生、发展、复发与转移是一个多基因、多途径相互作用的过程,基因表达的异常是肿瘤发生发展以及肿瘤浸润、转移的重要因素.研究从正常肝组织到肝炎、肝硬化、肝癌的发展过程中基因的改变及基因间相互作用的关系,对于明确肝癌的发生发展过程,阐明肿瘤的发病机制和肿瘤的治疗与预后都有重要的意义.

Multigenes and multigene interaction are involved in the development, recurrence and metastasis of hepatocellular carcinoma, while aberrant gene expression is the significant cause of recurrence and metastasis. Researches on gene changes and gene interaction in hepatitis, liver cirrhosis and hepatocellular carcinoma are important for identifying the development, elucidating the pathogenesis, and guiding the prognosis and therapy of hepatocellular carcinoma.