肠上皮屏障与炎症性肠病研究进展

Advance in enteric epithelial barrier and inflammatory bowel disease

肠上皮屏障损伤是近年炎症性肠病(inflammatory bowel disease,IBD)细胞和分子发病机制研究的新领域.肠上皮屏障是肠黏膜的重要防线之一,若受损则可引起肠上皮通透性增加,在IBD发病过程中起重要作用.目前研究重点侧重于肠上皮细胞和细胞间紧密连接结构和功能的改变,维持和修复肠上皮屏障可望成为治疗IBD的新策略.

Enteric epithelial barrier injury is a new field of the study on the cellular and molecular pathegenesis of inflammatory bowel disease （IBD） in recent years. The enteric epithelial barrier is one of the most important line of defense. Once the enteric epithelial barrier, one of the most important defense line in intestinal mucosa, is damaged, the permeability of enteric epithelium will increase, which is significantly involved in the genesis of IBD. At present, most researches mainly concentrate on the changes of intestinal epithelial cells and the structure and function of intercellular tight junction. Maintenance and repair of enteric epithelial barrier may be the ideal strategy for IBD therapy.