阿立哌唑与舒必利治疗以阴性症状为主的精神分裂症对照观察

Controlled study of aripiprazole and sulpiride in the treatment of schizophrenia with negative symptoms as the main axpression

目的:探讨阿立哌唑与舒必利治疗以阴性症状为主的精神分裂症患者的疗效和不良反应。方法:对60例以阴性症状为主精神分裂症患者,随机分为阿立哌唑组和舒必利组进行治疗,疗程8周。于治疗前及治疗后2、4、8周末用阴性症状量表(SANS)、简明精神病评定量表(BPRS)评定临床疗效,用不良反应量表(TESS)评定药物不良反应。结果:阿立哌唑组与舒必利组在治疗前后SANS、BPRS总分及减分率比较差异无显著性(P>0.05),各组治疗后SANS、BPRS总分与治疗前比较差异有显著性(P<0.01)。阿立哌唑在兴趣社交缺乏因子的疗效优于舒必利(P<0.05)。结论:阿立哌唑对以阴性症状为主的精神分裂症有肯定的疗效,在某些方面优于舒必利,安全性较高。

Objective：To compare the chnieal efficacy and side effects of aripiprazole and sulphide in the treatment of schizophrenia with negative symptoms as the main expression.Methods：60 eases of schizophrenia with negative symptoms as the main expression were randomly divided into aripiprazole group and sulphide group for 8 weeks. The clinical efficacy and side effects were evaluated with SANS,BPRS and TESS before and 2,4,8 weeks after treatment respectively. Results：Before treatment,the total scores and decreasing scores of SANS and BPRS had no significant differences between the two groups. After treatment, the total scores of SANS and BPRS were significantly decreased in each group. The efficacy of aripiprazale in anhedonia was better than that of sulpiride.Conchlsion：Aripiprazole is an effective and safe antipsychotic in the treatment of chizophrenia with negative symptoms as the main expression.