不同机械通气方式在新生儿肺出血中的应用比较

High frequency oscillatory ventilation in neonates with pulmonary hemorrhage

目的:观察高频振荡通气(HFOV)叠加常规机械通气(CMV)的通气方式治疗新生儿肺出血的疗效。方法:将新生儿肺出血18例随机分为治疗组和对照组,治疗组采用HFOV+CMV治疗,对照组采用CMV治疗,比较两组患儿的呼吸机参数和氧合指标情况。结果:两组病死率无明显差异,HFOV+CMV治疗24h后,氧合指数明显下降且低于CMV对照组,两组比较差异有显著性(P<0.05);患儿的肺出血停止时间、撤机时间比对照组短,差异有显著性(P<0.05)。结论:HFOV+CMV通气方式对新生儿肺出血能更好改善氧合,减少气道伤,缩短病程,疗效好而安全。

Objective ：To investigate and evaluate the application and safety of high frequency oscillatory ventilation （HFOV） in the treatment of neonates with pulmonary hemorrhage. Methods：The neonates with pulmonary hemorrhage were randomly divided into two groups,treatment group （n=12） and control group （n=12）. The treatment group was treated with HFOV,and the control group was treated with conventional mechanical ventilation （CMV）. Changes of oxygen and respiratory ventilation parameters were observed in 24 hours be- fore and after the therapy.Results：There was no difference between two groups in neonate mortality;The changes of oxygen parameters in the treatment group （HFOV） were distinctly lower than those in the control group （CMV）;There was significant difference between two groups （P〈0.05）. There was significant difference between two groups （P〈0.05） in the surviving neonates compared with other parameters （the time of pulmonary hemorrhage and the time of ventilation）. Conclusion：Compared HFOV and CMV treatment for neonates with pulmonary hemorrhage, the former is better in ventilation effect and oxygenation improvement, and also more safe and effective.