摘要
成人骨髓是血细胞再生的场所,也是形成血管的内皮祖细胞,能分化为脂肪细胞、软骨细胞及成骨细胞的间充质干细胞等脚,是干细胞或祖细胞的储存场所。早期的研究显示。化疗康复的患者外周血中造血祖细胞增加,因此认识到造血干细胞和造血祖细胞可从骨髓诱导出来,称之为“干细胞动员”。这些被动员的细胞可以聚集,也可以再返回骨髓行使其造血功能。诱导人血的造血细胞可用于移植。新的干细胞的诱导分离相关研究结果显示,造血于细胞的定量、定性研究及其潜在的作用和外周血造血干细胞移植的疗效是目前研究的热点翻。
出处
《现代医药卫生》
2008年第22期3409-3411,共3页
Journal of Modern Medicine & Health
参考文献18
-
1Caplan AI. Adult mesenehymal stem cells for tissue engineering versus regenerative medieine[J].J Cell Physiol, 2007,213:341.
-
2Pelus LM.Peripheral blood stem cell mobilization:new regimens, new cells,where do we stand[J].Curr Opin Hematol,2008,15: 285.
-
3To LB, Haylock DN, Simmons PJ,et al.The biology and clinical uses of blood stern cells[J].Blood, 1997,89:2233.
-
4Read E J, Scheinberg P. Mobilization collectionand immunomagnetie selection of peripheral blood CD34 ceils in recovered aplastic anemia patients[J].Transfusion, 2007,47:1250.
-
5Russell N, Mesters R,Schubert J,et al. A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin's lymphoma receiving chemotherapy[J].Haematologica, 2008,93 : 405.
-
6Hosing C ,Qazilbash MH, Kebriaei P,et al. Fixed-dose single agent pegfilgrastim for peripheral blood progenitor cell mobilisation in patients with multiple myeloma[J]. Br J Haematol,2006,133:533.
-
7Kroschinsky F,Holig K,Poppe-Thiede K,et al.Single-dose pegfilgrastim for the mobilization of allogeneic CD34^+ peripheral blood progenitor cells in healthy family and unrelated donors[J]. Haematologica, 2005,90 : 1665.
-
8Pelus LM ,Fukuda S. Chemokine-mobilized adult stem cells; defining a better hematopoietic graft[J].Leukemia,2008,22:466.
-
9Pelus LM,Broxmeyer HE. Chemokine axes in hematopoietie stem cell mobilization.In: Neote K,Letts GL,Moser B.editors. Chemokine biology-basic research and clinical applieation[M].Vol Ⅱ. Pathophysiology of chemokines[J].Basel: Birkhauser Verlag AG,2007.125.
-
10Broxmeyer HE ,Orsehell CM ,Clapp DW ,et al.Rapid mobilization of routine and human hematopoietic stem and progenitor cells with AMD3100,a CXCR4 antagonist[J]J Exp Med,2005,201:13078.
-
1葛静兰,王培华,邢立香.献血与健康[J].中国健康教育,2000,16(3):133-133. 被引量:6
-
2马建英,陆霞,谭宏.护理干预对造血干细胞移植患者自我管理能力的影响[J].中国急救复苏与灾害医学杂志,2009(11):887-889. 被引量:1
-
3徐贤,马林,安宁豫,蔡幼铨,刘新球.健康成人骨髓全身磁共振扩散加权成像研究[J].中国医学影像学杂志,2013,21(6):401-405. 被引量:16
-
4周育平,胡元会,吴华芹,王阶,宋庆桥.缺血性心力衰竭中医证候与外周血干细胞的相关性研究[J].中国中西医结合杂志,2009,29(9):798-801. 被引量:6
-
5王建宁,敖忠芳.人类脐血CD_(34)^+细胞的研究进展[J].国外医学(输血及血液学分册),1995,18(5):291-294.
-
6王健.成人骨髓移植受者中细菌、病毒和真菌感染调查[J].传染病网络动态,2001(8):6-7.
-
7余景星,刘心(综述).造血干细胞移植治疗实体瘤研究进展[J].国际肿瘤学杂志,2008,35(11):823-826.
-
8献血后不宜多喝茶[J].中国保健营养,1997(11):44-44.
-
9王广宇,朱旅云,马利成,单巍,刘淑艳,李晓玲,胡丽叶,王秀慧,杨少玲.治疗糖尿病足术前行干细胞动员的临床研究[J].实用糖尿病杂志,2008,4(4):62-62.
-
10姜华.髓芯减压联合自体外周血干细胞治疗早期股骨头坏死的疗效[J].广东医学,2013,34(13):2073-2074. 被引量:5